The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and marginally soluble in Alcoholic beverages. The molecular body weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it has the next chemical framework.
For nausea and vomiting in little ones, the standard dose is 0.five mg per pound of system excess weight, as well as the dose need to be modified on the age and excess weight in the affected person and the severity of your issue remaining taken care of.
If adrenal insufficiency is diagnosed, take care of with physiologic replacement doses of corticosteroids. Wean the individual off with the opioid to permit adrenal functionality to Get better and carry on corticosteroid remedy until eventually adrenal functionality recovers. Other opioids might be attempted as some circumstances described utilization of a distinct opioid devoid of recurrence of adrenal insufficiency. The knowledge offered isn't going to recognize any specific opioids as getting a lot more likely to be connected with adrenal insufficiency.
Therapy adjunctive to meperidine or other analgesics for Charge of postoperative soreness. Sedation in each little ones and Grown ups, together with relief of apprehension and production of mild slumber from which the client is often easily aroused.
Promethazine HCl Oral Resolution must be used with caution in individuals with bone-marrow melancholy. Leukopenia and agranulocytosis are described, normally when Promethazine (Promethazine HCl) has been used in Affiliation more info with other known marrow-poisonous agents.
Narcotic analgesics may perhaps trigger nausea and vomiting by stimulating the chemoreceptor bring about zone (CTZ); however, Additionally they depress the vomiting Centre, to ensure subsequent doses are not likely to provide vomiting. Nausea is minimum after standard oral doses of codeine.
For preoperative medication, youngsters have to have doses of 0.five mg per pound of entire body body weight together using an appropriately lowered dose of narcotic or barbiturate and the appropriate dose of the atropine-like drug.
Excessively huge dosages of antihistamines, which includes Promethazine HCl Oral Remedy, in pediatric patients may well lead to sudden Demise (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine in pediatric patients. In pediatric clients who're acutely sick connected with dehydration, There's an elevated susceptibility to dystonias with the use of Promethazine HCl.
Sedation This item relieves apprehension and induces a silent sleep from which the patient is often effortlessly aroused.
An increased threat of certain malformations with codeine exposure like respiratory malformations, spina bifida and congenital heart defects were reported in certain experiments.
Although antihistamines are actually discovered to supply fetal mortality in rodents, the pharmacological outcomes of histamine from the rodent never parallel those in man. There are no adequate and well-controlled scientific studies of Promethazine HCl Oral Remedy in pregnant Ladies.
This may be worsened if taken with alcohol or other drugs that also result in central anxious program (CNS) slowing for example sedatives, ache medicines, tranquilizers or specific medication for melancholy.
Stimulation may very well be obvious, particularly in small children and geriatric patients. Convulsions may perhaps not often take place. A paradoxical reaction has actually been documented in kids acquiring single doses of seventy five mg to 125 mg orally, characterised by hyperexcitability and nightmares.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, demanding thorough thing to consider of the consequences to the guardian drug, codeine, plus the Energetic metabolite, morphine.